February 21, 2024


Future Depends on What You Do

Amino acid and antioxidant offer you coronary heart well being gains in write-up-menopausal females

The endothelium is a slender membrane that lines the inside of the heart and blood vessels and endothelial cells launch substances that control vascular rest and contraction.

Postmenopausal women (PMW) may perhaps expertise endothelial dysfunction related with arginine (ARG) deficiency relative to asymmetric dimethylarginine (ADMA) induced by oxidative pressure. This can develop into arterial stiffness​ and hypertension​ in healthier postmenopausal females.

A further system for hypertension in postmenopausal girls is elevated sympathetic exercise​. Evidence suggests that augmented systolic blood tension (BP) reactivity to a sympathetic stimulus (chilly pressor test, CPT) predicts potential hypertension​ and heart failure​.

Nitric oxide (NO) is the main vasodilator (that means it dilates blood vessels) and this is manufactured from the amino acid L-arginine (ARG) by endothelial NO synthase (eNOS). Dietary techniques to enhance circulating ARG could improve vascular functionality but oral ARG becomes ineffective when there is stimulation of arginase activity (brought on by irritation).

Citrulline (CIT) inhibits arginase exercise​, and thus, has been uncovered to be far more effective​ than oral ARG in growing circulating ARG concentrations. 

The goal of this research was to examine the results of supplementing day by day for 4 weeks with CIT alone and CIT together with the antioxidant glutathione (GSH) on vascular purpose, assessed by brachial movement-mediated dilation (FMD, a biomarker for predicting cardiovascular function)​, arterial stiffness, and BP reactivity to CPT in postmenopausal women of all ages. Moreover, they assessed fasting blood glucose (FBG), serum levels of ARG and its metabolites, and markers of oxidative tension.